Angiographic Outcomes in the PLATO Trial (Platelet Inhibition and Patient Outcomes)
نویسندگان
چکیده
منابع مشابه
Angiographic outcomes in the PLATO Trial (Platelet Inhibition and Patient Outcomes).
OBJECTIVES The PLATO (Platelet Inhibition and Patient Outcomes) angiographic substudy sought to compare the efficacy of ticagrelor versus clopidogrel with respect to angiographic outcomes before and after PCI in the setting of acute coronary syndrome. BACKGROUND Greater platelet inhibition has been associated with improved angiographic outcomes before and after percutaneous coronary intervent...
متن کاملTicagrelor compared with clopidogrel by geographic region in the Platelet Inhibition and Patient Outcomes (PLATO) trial.
BACKGROUND In the Platelet Inhibition and Patient Outcomes (PLATO) trial, a prespecified subgroup analysis showed a significant interaction between treatment and region (P=0.045), with less effect of ticagrelor in North America than in the rest of the world. METHODS AND RESULTS Reasons for the interaction were explored independently by 2 statistical groups. Systematic errors in trial conduct ...
متن کاملBleeding complications with the P2Y12 receptor antagonists clopidogrel and ticagrelor in the PLATelet inhibition and patient Outcomes (PLATO) trial.
AIMS More intense platelet-directed therapy for acute coronary syndrome (ACS) may increase bleeding risk. The aim of the current analysis was to determine the rate, clinical impact, and predictors of major and fatal bleeding complications in the PLATO study. METHODS AND RESULTS PLATO was a randomized, double-blind, active control international, phase 3 clinical trial in patients with acute ST e...
متن کاملST-elevation acute coronary syndromes in the Platelet Inhibition and Patient Outcomes (PLATO) trial: insights from the ECG substudy.
BACKGROUND Ticagrelor, when compared with clopidogrel, reduced the 12-month risk of vascular death/myocardial infarction and stroke in patients with ST-elevation acute coronary syndromes intended to undergo primary percutaneous coronary intervention in the PLATelet inhibition and patient Outcomes (PLATO) trial. This prespecified ECG substudy explored whether ticagrelor's association with vascul...
متن کاملCoronary Heart Disease Ticagrelor Compared With Clopidogrel by Geographic Region in the Platelet Inhibition and Patient Outcomes (PLATO) Trial
Background—In the Platelet Inhibition and Patient Outcomes (PLATO) trial, a prespecified subgroup analysis showed a significant interaction between treatment and region (P 0.045), with less effect of ticagrelor in North America than in the rest of the world. Methods and Results—Reasons for the interaction were explored independently by 2 statistical groups. Systematic errors in trial conduct we...
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ژورنال
عنوان ژورنال: JACC: Cardiovascular Interventions
سال: 2013
ISSN: 1936-8798
DOI: 10.1016/j.jcin.2013.03.014